A1C Level and Future Risk of Diabetes: A Systematic Review
نویسندگان
چکیده
We examined ranges of A1C useful for identifying persons at high risk for diabetes prior to preventive intervention by conducting a systematic review. From 16 included studies, we found that annualized diabetes incidence ranged from 0.1% at A1C <5.0% to 54.1% at A1C >or=6.1%. Findings from 7 studies that examined incident diabetes across a broad range of A1C categories showed 1) risk of incident diabetes increased steeply with A1C across the range of 5.0 to 6.5%; 2) the A1C range of 6.0 to 6.5% was associated with a highly increased risk of incident diabetes, 25 to 50% incidence over 5 years; 3) the A1C range of 5.5 to 6.0% was associated with a moderately increased relative risk, 9 to 25% incidence over 5 years; and 4) the A1C range of 5.0 to 5.5% was associated with an increased incidence relative to those with A1C <5%, but the absolute incidence of diabetes was less than 9% over 5 years. Our systematic review demonstrated that A1C values between 5.5 and 6.5% were associated with a substantially increased risk for developing diabetes.
منابع مشابه
Response to Comment on: Zhang et al. A1C Level and Future Risk of Diabetes: A Systematic Review. Diabetes Care 2010;33:1665–1673
The recent systematic review by Zhang et al. (1) prompted us to examine A1C and risk factor data that were collected in Canada last year as part of a series of CANRISK diabetes screening projects (2). These data include both selfreported risk factors required to calculate the FINDRISC diabetes risk score (2) as well as A1C and standard glucose tests (fasting plasma glucose and 2-h 75-g oral glu...
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